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2月26日，生殖醫(yī)學(xué)領(lǐng)域國際權(quán)威期刊《Biology of Reproduction》在“RESEARCH HIGHLIGHTS”專欄，以“UHRF1: a jack of all trades, and a master epigenetic regulator during spermatogenesis”為題，亮點報道了華中科技大學(xué)同濟醫(yī)學(xué)院生殖健康研究所袁水橋教授課題組發(fā)表在Nature Communications的研究成果（Juan Dong^#, Xiaoli Wang^#, Congcong Cao^#, Yujiao Wen, Akihiko Sakashita, Si Chen, Jin Zhang, Yue Zhang, Liquan Zhou, Mengcheng Luo, Mingxi Liu, Aihua Liao, Satoshi H. Namekawa, Shuiqiao Yuan*. UHRF1 suppresses retrotransposons and cooperates with PRMT5 and PIWI proteins in male germ cells. Nature Communications. 2019, 10(4705), doi: 10.1038/s41467-019-12455-4.）。

節(jié)選亮點報道內(nèi)容如下：

The recent study by Dong and colleagues adds to our knowledge about the essential roles that UHRF1 plays in vivo. Already recognized as a jack of all trades, this study establishes UHRF1 as a master regulator of epigenetic pathways during male germ cell development. Importantly, the observed infertility phenotype is highly relevant to human male reproduction as genetic polymorphisms in the human UHRF1 gene have been associated with oligospermia.

全文亮點報道鏈接如下：

https://academic.oup.com/biolreprod/advance-article-abstract/doi/10.1093/biolre/ioaa026/5758287?redirectedFrom=fulltext

生殖生物學(xué)(Biology of Reproduction)雜志是美國生殖研究學(xué)會的官方期刊，創(chuàng)刊迄今已50多年，發(fā)表關(guān)于生殖生物學(xué)領(lǐng)域的原創(chuàng)性研究成果，以及關(guān)于當前重要或有爭議主題的綜述和評論，一直是生殖生物學(xué)領(lǐng)域被引用最高的期刊。（文/ 王曉麗）